People using popular drugs known as proton pump inhibitors are found to have high risk of kidney disease.
People who take heartburn pills are at high risk of developing chronic kidney disease compared to those who do not use these drugs, a new study suggests.
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According to the latest study published in JAMA Internal Medicine, a class of drugs known as Proton pump inhibitors, one of the most commonly used drugs worldwide, can significantly increase the risk of chronic kidney disease among its users.
Proton pump inhibitors (PPIs) drugs are taken by millions of people every year and they are found to have various dangerous side effects. Though side effects occur rarely but still it’s a worrisome situation for health officials.
“There appears to be mounting observational evidence that PPIs – historically a class thought to be extremely safe – have some adverse effects,” said lead author Dr. Morgan Grams of Johns Hopkins University in Baltimore.
“Given the widespread use of PPIs, even relatively rare adverse effects can impact large numbers of people. Thus, I think it wise to be judicious in the use of PPIs.”
For the study, researchers looked at the data of two previous studies, 10,482 participants from Artherosclerosis Risk in Communities (ARIC) and 248,751 patients from Geisinger Health System in Pennsylvania.
Researchers have found that 322 people using PPIs in the ARIC study have more than 11% higher risk of developing kidney disease over an estimated period of 10 years while the risk among 16,900 patients using PPIs in the Geisinger Health System was 15.6 percent.
Though the study could not establish a direct link between the proton pump inhibitors and chronic kidney disease but shows an increased risk associated with the drug. The study stresses that further researchers are required to determine the actual relationship between the drug and kidney disease.
"These types of studies, these big data studies, can sometimes suggest a signal that something's going on, but I don't know if they prove it.” Dr Kenneth DeVault president of American College Gastroenterology said.
PPI drugs including Prilosec, Nexium and Prevacid are used for treating heartburn or indigestion. These medicines reduced the production of acid in the stomach and prevent from ulcers as well.