A five-country study of over 9,000 cancer patients with type 1 diabetes revealed higher risks for some cancers, but also lower risk for others.
A new large scale study linking cancer with diabetes is getting a lot of attention this week. The study evaluated data of over 9,000 people with Type 1 diabetes, most of them had Type 2 diabetes, with cancer. The data suggests that there is a higher risk for stomach, liver, kidney, endometrium and pancreas cancer for people with diabetes. The study though also found that the diabetes sufferers have a lower risk of getting prostate and breast cancer.
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The mixed results of the study question the value of the results for diabetes patients. Diabetes causes many known health problems. Cancer can be one one of them.
Detailed results from the study:
Persons with type 1 diabetes were identified from five nationwide diabetes registers: Australia (2000–2008), Denmark (1995–2014), Finland (1972–2012), Scotland (1995–2012) and Sweden (1987–2012). Linkage to national cancer registries provided the numbers of incident cancers in people with type 1 diabetes and in the general population. The researchers used Poisson models with adjustment for age and date of follow up to estimate hazard ratios for total and site-specific cancers.
A total of 9,149 cancers occurred among persons with type 1 diabetes in 3.9 million person-years. The median age at cancer diagnosis was 51.1 years (interquartile range 43.5–59.5). The hazard ratios (HRs) (95% CIs) associated with type 1 diabetes for all cancers combined were 1.01 (0.98, 1.04) among men and 1.07 (1.04, 1.10) among women. HRs were increased for cancer of the stomach (men, HR 1.23 [1.04, 1.46]; women, HR 1.78 [1.49, 2.13]), liver (men, HR 2.00 [1.67, 2.40]; women, HR 1.55 [1.14, 2.10]), pancreas (men, HR 1.53 [1.30, 1.79]; women, HR 1.25 [1.02,1.53]), endometrium (HR 1.42 [1.27, 1.58]) and kidney (men, HR 1.30 [1.12, 1.49]; women, HR 1.47 [1.23, 1.77]). Reduced HRs were found for cancer of the prostate (HR 0.56 [0.51, 0.61]) and breast (HR 0.90 [0.85, 0.94]). HRs declined with increasing diabetes duration.
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The study titled "Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals," authored by Bendix Carstensen, Stephanie H Read, Søren Friis, Reijo Sund, Ilmo Keskimäki, Ann-Marie Svensson, Rickard Ljung, Sarah H Wild and Joannes J Kerssens has been published in Diabetologia.