Bitter Plant Extract Amarasate Can Suppress Food Intake

Posted: Jun 6 2016, 3:55am CDT | by , in News | Latest Science News


Bitter Plant Extract Amarasate can Suppress Food Intake
Photo Credit: Getty Images

There could soon be a pill to reduce your calorie consumption as researchers have identified a bitter plant extract that can suppress food intake by stimulating the secretion of gut peptide hormones involved in appetite regulation.

Gut chemosensory mechanisms, particularly those involved in detecting and relaying to the brain the chemical composition of food during digestion, play an important role in regulating appetite and food intake.

The researchers hypothesized that activation of specific bitter taste receptors which are expressed throughout the gastrointestinal tract by hormone secreting 'enteroendocrine' cells, could also regulate food intake by triggering the release of satiety or 'fullness' hormones, a mechanism termed by the team as the "bitter brake."

The study was conducted by John Ingram and colleagues from the New Zealand Institute for Plant & Food Research Limited and University of Auckland, New Zealand.

The team screened over 900 plant extracts for their ability to stimulate enteroendocrine "I cell" hormone release before identifying a highly bitter, non-nutritive plant derived ingredient they have called "Amarasate extract" to take forward into clinical testing.

Twenty lean healthy male volunteers were recruited (mean body mass index 23.4 kg/m2) with 19 completing all three treatments within the randomized, double-blind study.

Treatments comprising 500 mg Amarasate extract or a placebo were administered for targeted intestinal (duodenal) or stomach (gastric) release.

The researchers found that, compared with placebo, both gastric and duodenal delivery of the Amarasate extract stimulated significant increases in the gut peptide hormones CCK, GLP-1 and PYY while significantly reducing total (lunch plus snack) meal energy intake by 218 calories and 226 calories, respectively.

However, no significant treatment effects were observed for any subjective ratings of appetite or nausea.

"We have demonstrated that activation of the 'bitter brake' mechanism by a bitter plant extract can stimulate the release of gut peptide hormones involved in appetite regulation and suppress subsequent feeding behavior in healthy men," the authors noted.

The findings were presented at the 2016 European Obesity Summit in Gothenburg, Sweden.

You May Like


The Author

<a href="/latest_stories/all/all/59" rel="author">IANS</a>
The Indo-Asian News Service (IANS) was established in 1986, initially to serve as an information bridge between India and its thriving Diaspora in North America. Now IANS is a full-fledged wire agency, putting out news 24x7 from around the world.




Leave a Comment

Share this Story

Follow Us
Follow I4U News on Twitter
Follow I4U News on Facebook

You Also Like


Read the Latest from I4U News