It has been found that different gut bacteria are the chief cause of obesity in many individuals.
Obesity is clearly related to the bacteria and microbes present in our guts. Thin people have different gut bacteria from fat people. When fecal implants were made from thin people to fat people, the fat people lost weight.
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Also the opposite occurred when fat people had their fecal implants put in thin people. They gained weight. There are more than a trillion different types of bacteria in our intestines.
They play a major role in the health of human beings. Acetate caused a release of insulin in rats. Many experiments were carried out with rodents to delineate the biochemical channels of obesity causation.
It was an interesting study, that got published in the journal Nature.
Those organisms that ate a high fat diet had greater levels of acetate in their guts. The beta cells in the pancreas secreted insulin which inhibited any fat burning in the rodents.
The chemical reactions that take place in the body upon the secretion of insulin are very complex. Insulin is basically a response to glucose that is introduced in the context of the body.
Also gastrin and ghrelin are released and they cause increased food consumption. The last thing which was determined was that the gut microbes had an effect on insulin levels in the body.
After fecal matter was transplanted between various mice with different weights, it was observed that gut microbes, acetate and insulin levels changed radically.
The gut definitely seems to have a brain of its own. In fact, what is called gut instinct or intuition is precisely this balance in the gut of myriad microbes. The body displays a very delicate balance.
Were any one factor to be altered, the gut microbes will change accordingly. With increased acetate levels in the diet, you get greater consumption of food.
So obesity and insulin resistance take root and you get the cycle of overeating that ends in metabolic syndrome. While this mechanism may have played an important role in the past when our cavemen ancestors feasted and fasted intermittently, today with all the overabundance of food, we tend to get tempted and overeat on a regular basis.
This results in the ten thousand diseases of civilization such as obesity, stroke, cancer and heart attack. Especially, obesity seems to be becoming more of a pandemic instead of just an epidemic.
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By now, it has been termed “Globesity” since it seems to have spread all over the global village and is not just confined to the United States where it began in the first place.