It is being said that long life and vibrant health may both have their roots in a muscle cell catalyst or enzyme.
Vigorous activity and going for lengthy time periods without food do not transform the key enzyme responsible for energy production. A recent study revealed this on a regular basis.
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SIRT3 is a very important enzyme which is crucial for metabolizing fat and energy creation. Found within the mitochondria of muscle cells, it pinpoints various proteins and changes their activity settings.
Every single cell in the body contains mitochondria since energy production is dependent on these organelles. A more thorough knowledge of mitochondria may help in finding out about how the healthy human body functions. SIRT3’s site within the muscle cell is of key importance.
It is also subject to change. A sample of healthy young men were separated into two groups. One of the groups exercised for an hour to test their endurance.
The other one fasted for 48 hours. Muscle biopsies were then taken after the exercise and fasting periods were over. The mitochondria were separated for study.
Although the levels of SIRT3 mRNA in the cells had decreased, its location remained pretty much the same. The muscle cells activate mitochondria proteins in response to stimuli.
This is so as to meet the energy demands of the cells. The regulation of the proteins remained the central process in this complex energy allocation scheme.
The large family of enzymes that SIRT3 belongs to are said to improve chances of living longer and having glowing health. Most of the data for this came from studies involving cell cultures and animals. Whether such is the case in humans remains a moot point.
The regulation of sirtuins in human beings is a far more complex process than that seen in animals. You cannot extrapolate from one to the other. That would be tantamount to a crime in biochemistry.
The current research is scanty at best yet it points the way for future studies which will better gauge this element of longevity and optimal health in humans.
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This study got published in Experimental Physiology.