Heartburn Drugs May Higher Heart Attack Risk

Posted: Jun 11 2015, 10:27am CDT | by , in Misc


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Heartburn Drugs May Higher Heart Attack Risk
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  • PPI in Antacids make users prone to Heart Attacks

Researchers have found out that use of antacids with PPI component has been found out to make users perceptible to heart attacks.

Now you gotta see what antacid you use. There are different kind of antacids and while they all seems the same to you but there are different compositions to each antacid.

Antacids with proton pump inhibitor are much likely to cause heart attack among patients, to be specific 16 to 21 percent chances that a person might develop cardiovascular diseases. The reason being that PPI affect the endothelium in blood vessels which in turn cause cardiovascular diseases. Circulation report in 2013 in which scientists showed how -- at a molecular level -- PPIs might cause long-term cardiovascular disease and increase a patient's heart attack risk.

This doesn’t stand for all antacids. An examination of 16 million clinical documents representing 2.9 million patients also showed that patients who use a different type of antacid drug called an H2 blocker have no increased heart attack risk.

Research at Stanford University School of Medicine has found that people who had no prior history of heart disease developed the disease and susceptibility to heart diseases with the use of PPI containing antacids.

"Our results demonstrate that PPIs appear to be associated with elevated risk of heart attack in the general population, and H2 blockers show no such association," said Dr. Nigam Shah, an assistant professor of biomedical informatics at Stanford.

The FDA estimates about 1 in 14 Americans has used proton pump inhibitors. In 2009, PPIs were the third-most taken type of drug in the U.S., and are believed to account for $13 billion in annual global sales.

STRIDE (Stanford Translational Research Integrated Database Environment) scanned the databases for patients who were prescribed proton pump inhibitors or other drugs, such as H2 blockers, and also looked to see if a given patient had a mention of having experienced a major cardiovascular event, such as myocardial infarction (heart attack), in their medical record.

Patients who had used PPIs were found to be at 1.16-1.21-fold-increased risk of heart attack. PPIs are easily sold over the counter and prescribed by doctors worldwide. This large data indicates that another formula will have to be found out to replace PPIs.

The study was published on Wednesday in PLOS ONE.

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<a href="/latest_stories/all/all/20" rel="author">Sumayah Aamir</a>
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