New Cancer Drugs Research Database Now Modified To 3D

Posted: Jan 4 2016, 8:07am CST | by , Updated: Jan 4 2016, 8:27pm CST, in Latest Science News


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Cancer database goes 3D
Photo credit: Cancer Research UK

3D structures have been added to the largest database for cancer drug discovery in the world, making it easier for cancer scientists across the world to access cancer information with a view to developing effective drugs.

According to a report published in the journal Nucleic Acid Research by the Cancer Research UK, the 3D addition to the new canSAR database would allow for easy mapping of communication networks within cancer cells as well as for easy identification of faulty proteins.

The new canSAR database was developed at The Institute of Cancer Research in London, and is geared at empowering cancer scientists to design new cancer treatments without any hassles. First started in 2011 by the Cancer Research UK Cancer Therapeutics Unit of The Institute of Cancer Research, the canSAR database was launched to map how most of human cancer cells act out.

The database has billions of experimental researches analyzing how millions of drugs and chemicals act on human proteins, and these information have been added to genetic information and other findings from clinical tests.

The latest 3D canSAR technology relies on artificial intelligence to map the surface of problematic molecules causing cancer, with the view to developing drugs that will inhibit them. The new canSAR version also helps researchers to know the communication lines within tumor cells and know how to block these with new drugs.

Still growing, the database already has 3D structures of about 3 million cavities on about 110,000 molecules.

"Our database is constantly growing with information and is the largest of its kind - with more than 140,000 users from over 175 countries,” said Dr. Bissan Al-Lazikani, team leader in computational biology at The Institute of Cancer Research, London, who led the Cancer Research UK-funded team that developed canSAR. “And we regularly develop new artificial intelligence technologies that help scientists make predictions and design experiments. Our aim is that cancer scientists will be armed with the data they need to carry out life-saving research into the most exciting drugs of the future.”

Dr. Kat Arney, Cancer Research UK's science information manager, added that "This database makes masses of detailed scientific information about cancer available to scientists all over the world, and will speed up crucial advances in drug discovery - ultimately saving more lives.”

Dr. Arney noted that it takes a long time and very expensive processes to find new cancer drugs or treatment methods, and anything that will reduce this time and the costs involved should be welcome on the road to defeating cancer once and for all.

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The Author

<a href="/latest_stories/all/all/52" rel="author">Charles I. Omedo</a>
Charles is covering the latest discoveries in science and health as well as new developments in technology. He is the Chief Editor or Intel-News.




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