Enzyme That Neutralizes Sugar, Fat Deposits Found In The Body

Posted: Jan 14 2016, 11:06pm CST | by , in News | Latest Science News

Blood sugar level
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Researchers from the University of Montreal Hospital Research Centre (CRCHUM) have published a study in the journal Proceedings of the National Academy of Sciences detailing the new discovery of an enzyme named “glycerol 3-phosphate phosphatase” (G3PP).

The enzyme is noted to neutralize the harmful effects of sugar on various body organs, while also promoting fat utilization – a discovery that can aid the development of drugs for patients of obesity and diabetes, and also the production of sugar-free treats.

The research was carried out by Dr. Marc Prentki, Director of the Montreal Diabetes Research Center, a research network financed by grants from the Canada Foundation of Innovation; and Dr. Murthy Madiraju among other researchers. Dr. Prentki is also a principal investigator at the CRCHUM and a professor at the University of Montreal.

"When glucose is abnormally elevated in the body, glucose-derived glycerol-3 phosphate reaches excessive levels in cells, and exaggerated glycerol 3 phosphate metabolism can damage various tissues,” he said. “We found that G3PP is able to breakdown a great proportion of this excess glycerol phosphate to glycerol and divert it outside the cell, thus protecting the insulin producing beta cells of pancreas and various organs from toxic effects of high glucose levels."

Humans and other large mammals make use of fatty acids and sugar/glucose to maintain body functions; the internal utilization of glucose and fatty acids within body cells determine other body activities such as insulin secretion, glucose secretion by the liver, fat storage and metabolism for the release of energy.

When any of these internal processes is disrupted, it raises the risks of type 2 diabetes, obesity, and cardiovascular diseases among others. Insulin is necessary for maintaining adequate levels of glucose and fat, and its secretion is largely dependent on the amount of blood glucose within body cells.

However, diabetes and other physiological dysfunction could result when there is excess fatty acids and glucose in the blood, making them toxic to the system, causing gradual organ damage. But when there is proper utilization of glucose in the body cells, G3PP enzyme is created and this helps for body metabolism and the proper utilization of energy and fat.

"By diverting glucose as glycerol, G3PP prevents excessive formation and storage of fat and it also lowers excessive production of glucose in liver, a major problem in diabetes," says Murthy Madiraju, a scientist at CRCHUM.

"We identified the enzyme while looking for mechanisms enabling beta cells to get rid of excess glucose as glycerol,” Madiraju added. “This mechanism has also been found to be operating in liver cells, and this enzyme is present in all body tissues".

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The Author

<a href="/latest_stories/all/all/52" rel="author">Charles I. Omedo</a>
Charles is covering the latest discoveries in science and health as well as new developments in technology. He is the Chief Editor or Intel-News.




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