Protein Blueprint Of Pain And Heat Discovered

Posted: Jan 20 2016, 8:39am CST | by , in News | Latest Science News

 
Protein Blueprint of Pain and Heat Discovered
Mark A. Herzik Jr. of Scripps Research Institute
  • Protein Blueprint tied to Feelings of Pain and Temperature may aid in Analgesic Therapy

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A protein blueprint tied to feelings of pain and temperature may aid immensely in future analgesic therapy. Patients suffering from chronic pain will find relief thanks to this finding.

Scientists have discovered an ion-channel protein that is situated on the surface of cell membranes. Besides sensing heat, this protein could also lead to many therapies that block pain signals in chronically affected patients.

When people touch an extremely hot object, they instantly jerk their body part away from it since the sensors in the skin relay signals to the brain about the intense heat. Thus any injury is avoided by withdrawing the body part before permanent harm has been done.

The problem with chronic pain sufferers is that the debilitating pain is felt in the absence of any harmful object in the surrounding atmosphere. The pain just wouldn’t go away no matter what steps the patient takes to alleviate the distress.

The study was published in the journal Nature Structural Biology and Molecular Biology on January 18, 2016. It could pave the path to a cure for chronic pain.

Pain reception is where the crux of the matter lies. At present, chronic pain is not only ignored as being all in the mind but any effective treatments for it are few and far between. Over a hundred million Americans suffer from this troublesome illness.

The pain and heat receptors on the skin play an important role in the detection of any stimuli that are harmful to the human body. The outcome of the study is that some of the mystery of the unnecessary pain and suffering has been solved.

How the receptors function is of the greatest importance. The cell membranes have proteins on them that serve as channels that either relay signals or stop them.

The TRPV receptors allow the information to be changed to calcium ions. TRPV receptors open when the stimuli exceeds a certain threshold or limit.

Thus the calcium ions enter the brain and the brain senses heat or pain. A blueprint was made of the protein thereby helping researchers possess a model for future pain relief methodologies.

More effective medicines could be created in the times to come which will target pain reception. TRPV1 is available in the nervous system. TRPV2 on the contrary is found throughout the body.

Cryo-electron microscopy was employed to construct the blueprint from scratch. The two proteins were found to be different in their details. TRPV2 has a third state that is one of relative peaceful and painless numbness.

It is this state or phase that has to be brought about if chronic pain is to be treated on a fundamental level. More work is needed to delve into the depths of this biochemical tangle of knowledge. Only then will chronic pain be a thing of the past.

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<a href="/latest_stories/all/all/20" rel="author">Sumayah Aamir</a>
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