Chemistry Trick Leads To More Safer Medication For Type 1 Diabetes Patients

Posted: Mar 2 2016, 5:57am CST | by , in News | Latest Science News

Chemistry Trick Leads to More Safer Medication for Type 1 Diabetes Patients
  • Chemical Trickery leads to more Reliable Delivery of Drugs for Diabetes Patients

Researchers have engaged in some chemical trickery that may lead to a more reliable delivery of drugs for diabetes patients.

Novel experiments that have been undertaken at the University of Copenhagen have led to steps to counter diabetes via a safer method. The pharmaceuticals needed by Type 1 diabetes patients could be delivered in a more suitable manner than at present.

35 million diabetics around the world will benefit from this state of affairs. The molecule of insulin will be transformed in the lab. As for the researchers, they are very much pleased with this arrangement.

“We have discovered an entirely new method of modifying a molecule – Insulin – that is important for 35 million diabetes patients. We are incredibly happy with that,” says Knud J. Jensen, who is a professor at the University of Copenhagen’s Department of Chemistry.

Diabetes normally happens when the insulin production or reception goes drastically wrong in the body. Thus the regulation of blood sugar levels goes haywire. You cannot reverse or do away with diabetes.

Once its presence is established in the body, it is there for life and can only be managed or treated with various palliative measures. If no drugs or precautionary methods are applied, the illness could kill the sufferer.

Many complications and issues arise with the unsuccessful treatment of this insidious malady. It is injections of insulin that allow for the more extreme side effects of the disease to be ameliorated.

The only problem is that insulin needs to be given in submininal doses throughout the day. As yet there is no methodology of administering these near constant doses of insulin.

Thus the maintenance of stable sugar levels becomes a headache of sorts. Naturally occurring insulin collects into grid-like constructs called hexameres.

3D model of new self-assembly nano-insulin. Fig. B. Model of insulin molecules assembled in grid construction. Each hexamer (hexagon with six red bipyridin “hooks”) connects to another hexamer at an iron (II) ion (blue) at the end of each bipyridin

The task before biochemists was to create a form of insulin that showed equal homogeneity in its nanostructure. Its uniform assembly will mean that it can be released in small spurts instead of in the form of massive doses.

Experts have managed to solve this problem in a satisfactory manner. Insulin that has been created in the lab is allowed to self-assemble itself into grids. Bipyridine lies at the tail end of each insulin molecule.

It is the hook which is used to link up with other insulin molecules. Via the hooking of an iron ion to the bipyredine, chemists can control insulin assembly with extreme finesse. This procedure has been shown to be successful in lab rats.

The Iron Method is very different in its nature from the past injection system. It is the assembly of insulin that leads to its proper release in the body. This occurs from its stored depots beneath the skin.

New kinds of medicine will be manufactured in the times to come for diabetes patient using this methodology. It will not only be suitable but far more efficient than the current methods of administering the drug.

Knud J. Jensen together with Technical University of Denmark (DTU) and Novo Nordisk researchers, he has published “Construction of Insulin 18-mer Nanoassemblies Driven by Coordination to Iron (II) and Zink (II) Ions at Distinct Sites” in the renowned journal, Angewandte Chemie.

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<a href="/latest_stories/all/all/20" rel="author">Sumayah Aamir</a>
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