Diabetes Research: The Latest Scientific Discoveries To Lead To Treatment

Posted: Oct 26 2016, 1:00pm CDT | by , Updated: Oct 26 2016, 7:33pm CDT, in Latest Science News


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Diabetes Research: The Latest Scientific Discoveries to Lead to Treatment
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  • Diabetes Research: The Latest Scientific Discoveries that Could Lead to Proper Treatment

A Short Introduction

Heart disease began in the 1930s, obesity hit the US for the first time in the 1970s and diabetes rates really shot up in the 1990s. It is a disease of civilization like the other two previous examples.

The causes may range from stress to genetic proneness all the way to a diet of refined carbohydrates. Yet with all the scientific arsenal at our disposal, we are fast approaching novel treatments for this curse of a disease.

Harvard and MIT may Soon have a Cure

A cure for type 1 diabetes may be closer than we think. Scientists have shown that they could switch off the disease in animals for a period of half a year. This is a miracle. In case of human beings, this may extend to far more years.

Insulin-making cells were manufactured in the lab by scientists in 2014. When these were transplanted in mice, the miracle spoken of before took place.

This research effort has truly bore fruit and it could mean that daily insulin injections will go into the dustbin of history soon. Instead transfusions of the special cells will be all that is required, according to Telegraph.

Diabetics can now have a virtual novel pancreas. 10% of all diabetics are type 1 and life for them is tough on a day to day basis. Yet with this strategy, their aches and pains can be alleviated in a jiffy.

Instead of being insulin-dependent, people can now be insulin-independent in the true sense of the word.

Miraculous Treatment for Diabetes

A bacteria-killing protein is present in an area of the body that hardly has anything to do with bacteria. This could be the pancreas, for example. Researchers were confused over this question for awhile.

Then they found that the protein was acting in a certain manner that was hardly expected. It was helping the pancreas regenerate insulin. The study was published in a journal.

Over 400 million people have diabetes on a global level. They ride the blood sugar rollercoaster on a daily basis and have to control this disease via drugs or regular injections.

Sometimes, if the disease is mild, lifestyle choices such as diet and exercise can allay the symptoms. Type 1 diabetes has to do with the immune system which goes awry.

A bacteria-killing protein called CAMP plays a role in this disease. Yet its exact role remains uncertain. The highest levels of the bacteria were found in the gut tissue. However it was also found in the pancreas where it was least expected.

It is apparently produced by the same tissues which makes insulin. Pancreatic function was thus liable to the influence of this bacteria. This points towards the possibility of novel treatments for type 1 and 2 diabetes.

Drug for Leukemia may Cure Type 2 Diabetes

Imatinib is a drug used to cure cancer. It is specifically used for the treatment of leukemia. However, it also treats type 2 diabetes. A team of scientists have found this side effect of the drug.

It also reduces any chances of hyperglyemia or obesity. Although TZD-based medicines are effective at improving glucose uptake, they have adverse effects and thus have been taken off the shelves of pharmacies.

This new type of medication shows promise for future times. TZD drugs are selective agonists for PPARy. This plays a role in the metabolism of glucose, storage of fat, control of the immune system and inflammation.

The phosphorylation of PPARy leads to diabetes. The removal of phosphoric acid also leads to anti-diabetic effects. The drug for cancer had the most salubrious effect in reducing diabetes symptoms via this methodology. When tested in mice, it proved to be a good prophylactic.

Way to Treat Type 2 Diabetes at a Nascent Stage

A novel target for drugs has been found and this strategy can treat type 2 diabetes. Blocking a cellular glucose sensor in the muscles may help prevent the disease in the first place.

Insulin response took a turn for the better after this procedure. A protein called MondoA was the key agent in obesity-related diabetes. 8% of Americans have type 2 diabetes. 25% of Americans are also at a risk for obesity.

Type 2 diabetes may destroy the kidneys, peripheral nerves and the retina. It all begins in insulin resistance. Skeletal muscle was concentrated on since it was the sort which was insulin-responsive.

The research ultimately led the experts to MondoA. MondoA tied up all the phenomena that were observed in the genesis of type 2 diabetes. Directly enhancing glucose uptake by muscles may lead to a possible cure for type 2 diabetes in the times to come.

A Toroidal Vortex Ring could Help Better Islet Cell Encapsulation Therapy

Researchers have made the latest cures for type 1 diabetes approach the stage of takeoff. Encapsulated islet cells is one field of treatment. It has the cells implanted beneath the skin.

They receive nourishment from the body and also produce insulin. The problem in type 1 diabetes as mentioned earlier is that the immune system goes wild. It kills the body’s own cells without any discrimination.

That is why transplants do not cure the disease. This therapy though coats the islet cells with a barrier so that the immune system cannot harm them directly, according to diabetes.co.uk.

The employment of a toroidal vortex ring in the operations is a new development. A new more stronger method will have to be developed of producing the particles. Only then will the electrospraying take place and a nostrum for the malady be found.

Novel Contact Lens can Monitor Sugar Levels in the Blood in a Matter of Seconds

Contact lenses that can monitor blood sugar are the latest thing to hit the market. This invention was created by dedicated engineers. It could produce a revolution in diabetes research.

The lenses are not invasive and they analyze the sugar in the tears of the patients. They are ultimately connected to a small device that transmits data to the user’s smartphone.

Furthermore, they can be worn in the morning and taken off at night just like any other contact lenses. This is a very cool method of blood sugar testing which is a vast improvement over the finger pricking method.

Insulin Pill could Make Diabetes Cure a Painless Process

Millions of Americans have to inject themselves with insulin daily which is an invasive method. However, less painful methods are on the horizon. Oral intake of the medication is one area that holds great hope for future times.

A new technology called Cholestosome may change everything about the diabetes game. It is a lipid-based particle that can do a variety of things. The delivery of insulin orally is a big challenge.

The stomach acid sees to it that the pills are degraded. A polymer coating was considered for awhile but it turned out to be a dud. Cholestosomes instead package insulin so that the vesicles are natural lipids.

They are actually liposomes. The vesicles are outside and the drug is inside. The degradation is this shunted very carefully and craftily. This method allows the absorption of insulin in the intestines and thus its delivery to the bloodstream.

No More Blood

Now the extraction of blood for testing will be a thing of the past thanks to many novel discoveries made by scientists. Copper with a sponge-like porous structure can detect glucose in sweat or tears.

Monitors are expensive due to the use of platinum in their testing apparatus. Glucose sensors based on copper could be a game changer though. They will also be relatively inexpensive.

Also the conductivity will be excellent and the performance will be stellar. Copper degrades into something else when it is oxidized, which is one reason the Statue of Liberty is green in appearance.

Thus copper is combined with polystyrene thus leading to copper coated on small polystyrene balls. The cheap material comes in handy in testing for the presence of glucose in tears and sweat, according to Phys.org.

An Artificial Pancreas will Be Here in Two More Years

An artificial pancreas would be a blessing for those who have type 1 diabetes. It would pump insulin in their bodies and give them respite from the wicked disease that is diabetes.

Scientists are saying that we will have artificial pancreas by 2018. That is not such a faraway date. It is just two years from the present time. Although insulin pumps and glucose monitors are available now, an artificial pancreas will be a real game changer once it comes on the scene.

It will act like both devices and will simplify the issue in the blink of an eye. The hassles of monitoring and delivering injections will be a bygone thing. Furthermore, the delivery of insulin can then be so finetuned that the nasty and obnoxious symptoms of the disease can be kissed a hasty farewell.

FDA Approves World's First Artificial Pancreas for Patients with Diabetes

The FDA has given the go ahead signal for the world’s first Hybrid Closed Loop System for people with Type 1 Diabetes. FDA has given the thumbs up to the first artificial pancreas. This is a wonderful chapter in the fight against diabetes. It is basically a smartphone-sized gadget that autonomously sends insulin doses into the bloodstream and also takes readings of glucose levels. Thus it is a sort of two-in-one device. The approval by the FDA came as a pleasant surprise.

Mobile Technology can Aid Diabetic Patients

SMS via mobile phones can lead to a slashing of the casualties due to diabetes. Such advice and information as diet and exercise regimens and timely nutritional tidbits may help people avoid the pitfalls associated with diabetes.

At the level of the entire population, mobile technology can indeed come to the help of the masses in their quest to beat diabetes. All it takes is the right sort of advice and the best that medicine and nutritionists have to offer.

Public health messages are to be the latest series of attacks against the causes and gaffes that lead to the disease in the first place. The study looked at countries such as India which has a massive population.

Such mobile text messages which gave data which improved glucose readings and helped people lead healthier lives were the best way of beating this disease bit by bit and one step at a time.

Job Insecurity May Increase Diabetes Risk

Strange as it may seem, fear of unemployment probably causes the chances of contracting diabetes to increase by several degrees.

Blood glucose levels are 19% higher for those meek employees who are ever fearful lest they lose their jobs. These workers who remain apprehensive about getting the pink slip have a higher risk of getting type 2 diabetes.

The scientists took data from 141,000 workers in the United States, Europe and Australia. Their average age was 42. They found that the blood glucose rate was 19% higher for the cowardly and anxious workers who always thought the Sword of Damocles hung above them regarding job loss.

As compared to these people with job insecurity those who were secure in their positions and showed greater job satisfaction didn’t show such symptoms. Yet, this does not mean that the cause and effect relationship is as simple as it seems.

A Better Diabetes Test

The experts have figured out a mathematical formula for improving the standard diabates test by several degrees. This approach will probably enable physicians and their patients to control the blood sugar levels of the latter.

Also the high risk of heart attack, stroke, blindness and kidney disease that is linked with diabetes will be reduced. The central focus is the HbA1c test which is also known as the A1c test. It is a major test meant to diagnose diabetes.

This test measures pre-diabetes too. It also tracks blood sugar levels over a period of three months. The amount of glucose a person’s cells soak up is measured in a highly fine-tuned way.

Since the inception of these cells, they have become sensitive to sugar levels. Before this test was in existence, the only thing which was known with certainty was the person’s sugar levels.

Yet the most effective treatment could only be administered if the sugar levels in the cells since the erstwhile checkup could be known with any certainty. Tha A1c test provided this for the first time in the history of mankind.

Millions of diabetes patients have employed this special test to better their prospects as sufferers from this “sweet sickness” of a disease that causes so much devastation with the passage of time.

A mathematical formula or algorithm was used to analyze the blood sugar levels in the test. Thus variations in the age of the blood cells in the test were measured thanks to this math method.

The hemoglobin in the RBCs accumulates blood glucose over time and this is a major reason behind the differences in reading values. Over 200 patients were included in the study.

The extra expenses of this upgrading of the test were not gone into by the researchers. Lab methodology will benefit from this new algorithm in matters having to do with the future of diabetes tests.

Drinking Two Diet Drinks Daily Could Double Diabetes Risk

Apparently, two soft drinks taken at various times a day could increase the chances of contracting diabetes. This is so even if the soft drinks contain no sugar.

So-called diet versions are just as bad since the body does not differentiate between sucrose which is table sugar and saccharine which is artificial sugar. The study concerning this took place in Sweden. Over 2800 adults were included in the research effort.

Those individuals who drank two 200 ml servings of soft drinks each and every day were 2.4 times as likely to contract type 2 diabetes as those who did no such thing, according to Telegraph.

The majority of the soft drinks were sold in 330 ml cans which meant that even by drinking a can and a half of a serving, people were well on their way to contracting the “sweet sickness” that was diabetes.

As for those unfortunate souls who guzzled down a liter each day, they ended up being 10 times as prone to contracting diabetes as the rest of the soft drink teetotalers.

The really weird news was that this effect was extant whether one drank a standard soft drink or a diet version.

Despite the sugar being an artificial one in the diet version of the soft drink, the human body seems to be much more intelligent than we could fathom in our chemical acrobatics which we engage in inside the lab to make artificial food and drink.

Insulin resistance is the end result of drinking these crappy drinks that don’t have any nutrients in them. Even artificial sweeteners tend to make one crave sugars and one also tends to develop a sweet tooth as a result. Food intake also skyrockets.

Someone with type 2 diabetes should get up from desk for three or more minutes of light physical activity for every half hour

New guidelines by American Diabetes Association (ADA) included that three or more minutes of activity such as walking, leg extensions or overhead arm stretches every thirty minutes or so during the day. This step would break the monotony of hours upon hours of sitting all day long. Improvements in blood sugar were likely thanks to this strategy. Those with type 2 diabetes were the ones most likely to benefit from this arrangement. This is a change from the previous recommendations.

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The Author

<a href="/latest_stories/all/all/20" rel="author">Sumayah Aamir</a>
Sumayah Aamir (Google+) has deep experience in analyzing the latest trends.




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