Unique Hydrogel Heals Wounds By Prompting Skin Cells To Crawl

Posted: Dec 14 2016, 10:19am CST | by , in Latest Science News


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Unique Hydrogel Heals Wounds by Prompting Skin Cells to Crawl
U of T Engineering researchers Dr. Lewis Reis (at left) and Professor Milica Radisic used their unique peptide-hydrogel biomaterial to close non-healing wounds twice as quickly as commercially available products. Credit: Marit Mitchell / U of T Engineering
  • Hydrogel Heals Wounds through Cell Crawling Process

Non healing wounds in diabetes can be cured now through hydrogel.

New gel is developed by a team of researchers that can heal hard wounds.Professor Milica Radisic who leads the team declared, the peptide hydrogel stimulate skin cells to crawl together healing chronic wounds that are linked with diabetes. Such wounds include foot ulcers, and bed sores.

The scientists tested the biomaterial on keratinocytes taken from healthy skin cells, and keratinocytes from diabetic patients, especially elderly patients. The wounds healed 200 times faster than with no treatment, and 60 times faster than wounds treated with collagen products.

The team was happy to see fast healing on skin cells, and was worried if they won’t be able to heal chronic wounds in diabetic patients, said by Professor Radisic.

Before this discovery, most chronic wounds were treated with topical gels that cause blood vessels to grow. But, blood vessel growth is missing in diabetic patients, so the treatment becomes ineffective.

The team did research on QHREDGS peptide for 10 years. They found that the peptide healed different cells, like heart cells, stem cells, and fibroblasts.

Radisicand her team developed a hypothesis from this test, if they use peptide to heal skin cells through crawling process, it would heal the wound faster in diabetic patients.

Radisic and PhD students Yun Xiao and Lewis Reis took two gels, including Q-peptide-hydrogel without the peptide, and tested them on wounds. Just a single dose of peptide based gel healed the wounds within two weeks.

The team published this research in the journal Proceedings of the National Academy of Sciences.

Radisic and her team worked in collaboration with Covalon Technologies Ltd., a well-known research company. Dr. Val DiTizio, Chief scientist from Covalon led the group for three years and used his ColActive dressing during the research.

The researchers also found that, the discovered gel can also heal the wounds after heart surgery, and that can prevent infection.

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