New Drug Could Be First To Cure Type 2 Diabetes

Posted: Mar 30 2017, 1:51pm CDT | by , in News | Latest Science News

 
New Drug Could be First to Cure Type 2 Diabetes
  • A Novel Diabetes Medicine could Turn Back the Disease in its Tracks

It looks like a novel diabetes medicine has been invented which could turn back the disease in its tracks.

What if a time comes when there will be no need of insulin shots or the constant avoidance of sugar. A daily dose of a drug that can reverse symptoms of diabetes in mice may one day be used in human beings. Last year, four million people in the UK had diabetes. This was an increase of 65% over a ten years’ time span.

While 3.5 million have been correctly diagnosed with the disease, there is a dark figure of 550,000 who remain undiagnosed and most of them are obese and liable to contract the illness at a later time in their lives.

There are many people who develop type 2 diabetes as they age. The body stops responding to insulin. Insulin normally controls the amount of glucose levels present in the blood.

While many tend to follow a spartan diet along with the intake of medications to control the disease, there are side effects to the medications such as weight gain and loose stools.

Although the drugs can lead to diabetes management, they cannot reverse the ailment. The clock cannot be turned back on insulin resistance. So many individuals have to resort to taking shots of insulin.

If type 2 diabetes is left untreated, it causes among other things, heart and kidney disease, neuropathy, foot ulcers and optic problems. Diabetes reversal in the form of taking a single pill daily is what the scientists are after in the lab.

In mice, such an experiment has proven to be a success. It is humans in which the scientists are reluctant to test the drug. Whether the drug is safe in humans remains to be seen.

The drug accomplishes its task via a low molecular weight protein tyrosine phosphatase (LMPTP). This tends to contribute to cells losing their sensitivity to insulin. Via a hindering of this thing called LMPTP, the drug restarts the insulin receptors on the cellular surface.

One of the organs where this especially occurs is the liver. The gene responsible for the production of LMPTP often causes diabetes-like maladies, according to New Scientist. The experts investigated the matter further.

Animals whose gene had been stopped didn’t develop diabetes even when fed a high fat diet. LMPTP was thus the culprit in the whole diabetes and obesity equation.

Blocking LMPTP enzyme in the liver was where the real magic of diabetes reversal took place in earnest. This was indeed a form of targeted treatment of type 2 diabetes.

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